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KMID : 1103720200810020395
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Journal of the Korean Society of Radiology
2020 Volume.81 No. 2 p.395 ~ p.408
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Early Recurrence of Breast Cancer after the Primary Treatment: Analysis of Clinicopathological and Radiological Predictive Factors
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Yun Sun-Geun
An Yeong-Yi
Kim Sung-Hun
Kang Bong-Joo
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Abstract
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Purpose: To evaluate the value of clinicopathologic factors and imaging features of primary breast cancer in predicting early recurrence after the primary treatment.
Materials and Methods: We enrolled 480 patients who had been followed-up after breast-conserving surgery and adjuvant therapy from January 2010 to December 2014 at our hospital. Early recurrence was defined as recurrence within 3 years after completion of primary treatment, and univariate and multivariate logistic regression analyses were performed to determine the clinicopathologic and imaging predictive factors of early recurrence.
Results: In the univariate analysis, among the clinicopathologic factors, advanced stage (p = 0.021), high histologic grade (p < 0.001), estrogen receptor negative (p = 0.002), high Ki-67 proliferation index (p = 0.017), and triple-negative breast cancer (p = 0.019), and among the imaging features, multifocality (p < 0.001), vessels in the rim on Doppler ultrasonography (US) (p = 0.012), and rim enhancement (p < 0.001) on magnetic resonance imaging of the breast were significantly associated with early recurrence. In the multivariate analysis, advanced stage [odds ratio (OR) = 3.47; 95% confidence interval (CI) 1.12?10.73; p = 0.031] and vessels in the rim on Doppler US (OR = 3.32; 95% CI 1.38?8.02; p = 0.008) were the independent predictive factors of early recurrence.
Conclusion: Vascular findings in the rim of the primary breast cancer on Doppler US before treatment is a radiologic independent predictive factor of early recurrence after the primary treatment.
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KEYWORD
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Breast Neoplasms, Ultrasonography, Doppler Ultrasound, Recurrence
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